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Committees

ACTC Committees are composed of experts in the field who advise investigators and study teams during the development and conduct of ACTC Trials.
Biospecimen Allocation Review Committee
Chairs: Thomas Montine, MD, PhD
Early-Career Project Evaluation Committee
Chair: Ram Bishnoi, MD
Executive Committee
Internal Ethics Committee
Co-Chairs: Joshua Grill, PhD, Jason Karlawish, MD
Neuropsychiatric Symptoms Committee
Chair: Jeffrey Cummings, MD, ScD
Non-AD Dementia Committee
Co-Chairs: Bradley Boeve, MD, Adam Boxer, MD, PhD
Non-Pharmacological Intervention Committee
Co-Chairs: Laura Baker, PhD, Bruno Vellas, MD, PhD
Project Evaluation Committee
Co-Chairs: Christopher van Dyck, MD, Suzanne Craft, PhD
Publications Committee
Chair: Gad Marshall, MD
Research Partnership Alliance
Co-Chairs: Sarah Walter, MSc, Lupe Morales, MBA
Site Metrics and Study Budgets Committee
Co-Chairs: Suzanne Craft, PhD, Jonathan Graff-Radford, MD
Site Process Improvement, Networking, and Support Committee
Co-Chairs: Brielle Schreiter, Angelica Forero
Steering Committee

Biospecimen Allocation Review Committee

Chairs:
Thomas Montine
MD, PhD
Members:
Donna Wilcock
PhD
About:
The Biospecimen Allocation Review Committee is a panel of experts who review biospecimen applications (DNA, biofluids, and tissue) for scientific merit.

Early-Career Project Evaluation Committee

Chair:
Ram Bishnoi
MD
Vice Chair:
Adam Mecca
MD, PhD
IDEA-CT Unit Liaison:
Athene Lee
PhD
Members:
Kirsten Wright
ND, MCR, MS
Kyra O’Brien
MD
Elif Pinar Coskun
MD
Gregg Day
MD
Irina Skylar-Scott
MD
Parichita Choudhury
Patricia Andrews
MD
Mentors:
Karen Bell
MD
Neelum Aggarwal
MD
Gad Marshall
MD
Paul Newhouse
MD
About:
The Early-Career Project Evaluation Committee is a committee under the Inclusion, Diversity and Education in Alzheimer’s disease – Clinical Trials (IDEA-CT) Unit, charged with enhancing the training of early-career investigators in protocol review and development by providing a platform to contribute in the evaluation and selection of ACTC projects.

Executive Committee

Members:
Alesia Cole
MSN, RN, APNP, ACRP-CP
Amanda Smith
MD
Anton Porsteinsson
MD
Christopher van Dyck
MD
Clifford Jack
MD
Dorene Rentz
Dorene Rentz
PsyD
Gregory Jicha
MD, PhD
Gustavo Jimenez-Maggiora
PhD, MBA
Jeremy Pizzola
Joshua Grill
PhD
Keith Johnson
MD
Laurie Ryan
PhD
Matthew Frosch
MD, PhD
Michael Donohue
PhD
Michael Rafii
MD, PhD
Michael Weiner
MD
Paul Aisen
MD
Reisa Sperling
MD, MMSc
Rema Raman
PhD
Robert Rissman
PhD
Ronald Petersen
MD, PhD
Sharon Sha
MD, MS
Suzanne Craft
PhD
Vijay Ramanan
MD, PhD
About:
The Executive Committee is responsible for overseeing ACTC and advising leadership on key decisions. The committee reviews consortium governance and communications issues, and reviews the progress of ongoing ACTC clinical trials and discusses any challenges as they arise.

Internal Ethics Committee

Co-Chairs:
Joshua Grill
PhD
Jason Karlawish
MD
Members:
Judith Heidebrink
MD
Jonathan Graff-Radford
MD
Milap Nowrangi
MD, MBe
Gregory Jicha
MD, PhD
Seth Gale
MD
Charles Bernick
MD, MPH
Emily Largent
PhD, RN
About:
The Internal Ethics Committee monitors and manages the financial relationships (industry ties and intellectual property holdings) of individuals who have a role in protocol selection, development, and analyses; this includes unit leads, and members of the Project Feasibility Committee, Early-Career Project Evaluation Committee, Project Evaluation Committee, and Steering Committee. The committee develops policies to address these relationships and provides ACTC investigators, staff, and collaborators with ethics education and consultation.

Neuropsychiatric Symptoms Committee

Chair:
Jeffrey Cummings
MD, ScD
Members:
Anton Porsteinsson
MD
Brigid Reynolds
MSN, ANP-BC
Elaine Peskind
MD
Oscar Lopez
MD, FAAN
Paul Rosenberg
MD
Danielle Goldfarb
MD
Pierre Tariot
MD
About:
The Neuropsychiatric Symptoms Committee advises leadership on trial design for studies of agents, devices, or non-pharmacologic interventions targeting neuropsychiatric symptoms such as agitation, psychosis, depression, apathy, and sleep disorders. The committee also assists in designing trials for non-AD dementia such as frontotemporal dementia and dementia with Lewy bodies where behavioral symptoms are prominent, and encourages companies and others with psychotropic drugs to approach ACTC for review and possible trial conduct.

Non-AD Dementia Committee

Co-Chairs:
Bradley Boeve
MD
Adam Boxer
MD, PhD
Members:
Jonathan Graff-Radford
MD
Sharon Sha
MD, MS
Charles Bernick
MD, MPH
Lisa Silbert
MD, MCR
About:
The Non-AD Dementia Committee advises on trial design for ACTC projects with a non-AD population.

Non-Pharmacological Intervention Committee

Co-Chairs:
Laura Baker
PhD
Bruno Vellas
MD, PhD
Members:
Jeffrey Burns
MD, MS
Thomas Obisesan
MD, MPH
About:
The Non-Pharmacological Committee provides expertise and guidance in the development and management of ACTC projects involving non-pharmacological approaches in clinical trials, focusing on physical exercise, cognitive/social stimulation, diet/nutrition, and other exposures proposed to impact AD risk or trajectory (sleep, light, toxins, etc). The committee also encourages and facilitates the standardization of methods used to deliver and assess success of non-pharmacological interventions to support harmonization and data sharing across studies.

Project Evaluation Committee

Co-Chairs:
Christopher van Dyck
MD
Suzanne Craft
PhD
Members:
Jonathan Graff-Radford
MD
Paul Rosenberg
MD
Gregory Jicha
MD, PhD
Oscar Lopez
MD, FAAN
Po-Heng Tsai
MD
Stephen Salloway
MD
Laurie Ryan
PhD
Bradley Hyman
MD, PhD
About:
The Project Evaluation Committee performs preliminary evaluation of proposals submitted to ACTC for scientific merit, feasibility, and appropriateness. The committee votes on which proposals should be referred to the ACTC Steering Committee and prepares written feedback for proposers.

Publications Committee

Chair:
Gad Marshall
MD
Members:
Gregory Jicha
MD, PhD
Neelum Aggarwal
MD
Oscar Lopez
MD, FAAN
About:
The Publications Committee monitors publications using data from ACTC projects to ensure the accurate report of analyses and interpretation of results, and that the publications appropriately acknowledge ACTC. The committee ensures appropriate conflicts of interest are reported and intervenes with journal editors when necessary.

Research Partnership Alliance

Co-Chairs:
Sarah Walter
MSc
Lupe Morales
MBA
Members:
Cynthia Huling Hummel
Rochelle Long
Angela Aldebol
Dennis Chan
Nancy Childs
Scott Katke
Nancy Meserve
Michael Payne
Nyoka Seymore
Cynthia Sierra
Carol Turner
John Williams
About:
The Research Partnership Alliance is composed of individuals with lived experience in Alzheimer’s disease and related dementias who provide feedback to researchers concerning topics such as study design, ethical considerations, result sharing, privacy concerns, recruitment approaches, and inclusivity. By working together with researchers, the Research Partnership Alliance helps ensure that ACTC’s clinical trials are meaningful and relevant to the broader public and that these individuals can share their stories and advocate for progress in the fight against ADRD.

Site Metrics and Study Budgets Committee

Co-Chairs:
Suzanne Craft
PhD
Jonathan Graff-Radford
MD
Members:
Mary Sano
PhD
Martha Combs
MS
Kelly McCann
Thomas Obisesan
MD, MPH
Susie Sami
Alison Belsha
About:
The Site Metrics and Study Budget Committee is responsible for advising ACTC on measures of site performance (enrollment, screen failure rates, retention) and assisting ACTC in determining appropriate budgetary allocations for protocol activities. The committee aims to develop and implement a system of metrics for evaluating site performance, including standardized requirements for becoming an ACTC Member Site and standards for retaining ACTC membership and infrastructure support.

Site Process Improvement, Networking, and Support Committee

Co-Chairs:
Brielle Schreiter
Angelica Forero
Members:
Jaimie Ziolkowski
Sara Mason
BA, BSN, RN
Amelia Troutman
Martha Combs
MS
Molly Harper
Leslie Dunn
Susan Salem-Spencer
Shirley Sirivong
Tia Hall
Carolyn Liebsack
Susie Sami
Roma Patel
Karen Gagnon
Amy Boegel
PhD
Alison Belsha
About:
Recognizing that Site Research Managers and Study Coordinators are a critical component of AD clinical trial infrastructure, and that these roles require a special set of skills and need for support and training, this committee aims to improve infrastructure for AD clinical trials by providing support and mentorship through networking opportunities and providing feedback to ACTC leadership on how to best support training and career development. The committee also aims to improve site processes and study implementation through identifying and disseminating best practices for site and coordinating center processes.

Steering Committee

About:
The Steering Committee is composed of the principal investigators from each of the 38 ACTC Member Sites and the leads from each of the ACTC Units. The committee provides guidance on the management of ACTC, selects projects to be developed into grants, and guides study conduct.